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Advanced SystemCare Pro 12 Crack Portable : By DIY support teamThe effect of high-dose perioperative lignocaine on the incidence of post-operative pain: a randomised controlled trial.
Concerns over the safety of excessive local anaesthesia have led to hesitation in the administration of high-dose perioperative lignocaine. The objective of this study was to examine the efficacy of high-dose local anaesthesia in reducing the incidence of post-operative pain. A randomised controlled trial of 500 patients undergoing gynaecological or general surgery was performed. Patients were randomly assigned to one of two groups receiving either intrathecal lignocaine (6 mg/kg) or bupivacaine (15 mg/kg) at the time of induction of anaesthesia. Groups were comparable in terms of age, gender, pre-operative diagnosis and type of anaesthesia. Post-operatively, patients completed a five-point pain assessment scale and provided a visual analogue score (VAS) at rest and on movement. Pain scores and VAS were recorded at fixed intervals over the first 48 h after surgery. The incidence of adverse events was also recorded. The amount of local anaesthetic administered was significantly higher in the lignocaine group than in the bupivacaine group, and the lignocaine group experienced significantly more hypotension (17% vs. 5%) and post-operative nausea and vomiting (PONV) (24% vs. 10%). The mean (SD) pain scores for rest and on movement were significantly lower in the lignocaine group over the first 24 h after surgery, at 1 h after surgery (3.9 (2.2) vs. 4.7 (2.4), p = 0.0001) and at 24 h after surgery (2.5 (2.1) vs. 3.4 (2.3), p = 0.0001). Patients in the lignocaine group had a significantly lower incidence of moderate or severe pain (34% vs. 53%, p = 0.001), PONV (22% vs. 40%, p = 0.001), recall of post-operative pain (

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